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  • 元云飞

    职务:肝脏外科副主任
    职称:教授、主任医师、博士生导师
    专长:肝癌的外科治疗、介入治疗、靶向免疫治疗等
    一、基本情况
      职务:肝脏外科副主任
      职称:教授、主任医师、博士生导师
      专家门诊时间: 周一上午;周四上午
      专业特长:主要从事肝癌的外科治疗、介入治疗、靶向免疫治疗等。在中国率先应用ICGR15评估肝储备功能,熟练掌握各种复杂的肝切除术(如巨大肝癌切除术、肝尾状叶切除术、扩大半肝切除术,中肝叶切除术)等,对各种高难度肝脏外科手术及高危患者的围手术期处理积累了丰富的经验。

    二、学习及工作经历: 
      1978年—1983年:中山医学院医学系,获学士学位
      1983年—1986年:中国医学科学院血液学研究所工作
      1986年—1989年:中山医科大学外科学硕士研究生,获医学硕士学位
      1989年—1998年:中山大学附属肿瘤医院工作
      1998年—2000年:Baylor医学院进修学习
      2000年—2001年:美国MD Anderson癌症中心进修学习
      2001年至今:中山大学附属肿瘤医院肝胆科工作

     华南肿瘤学国家重点实验室PI,

    环球体育平台登录《Cancer Communications》杂志(原癌症杂志)编委(2003.01-至今),

    《岭南现代临床外科》杂志编委(2007.03-至今),

    环球体育平台登录《中华普通外科学文献(电子版)》杂志编委(2007.08-至今),

    环球体育平台登录《中华肝脏外科手术学电子杂志》编委(2012.12-至今)

    环球体育平台登录中国抗癌协会第六届肝癌专业委员会委员(2017.05.19-  )

    环球体育平台登录中华医学会肿瘤学分会第十一届委员会肝癌学组委员(2018.06.23-  )

    国际肝胆胰协会中国分会转移性肝癌专业委员会委员(2017.12-2021.12)

    广东省医学会肝癌分会第一届委员会副主任委员(2016.6- 2020.6 )

    环球体育平台登录广东省医学会外科学分会委员会第十届委员会常务委员(2018.10.15-  )

    环球体育平台登录广东省抗癌协会肿瘤转移专业委员会第二届委员会候任主任委员(2018.7-2022.7)

    环球体育平台登录广东省抗癌协会肝癌专业委员会第五届常委(2018.8-2022.8)


    环球体育平台登录  1962年10月出生。1983年毕业于中山医学院,获学士学位。1983年9月至1986年8月在天津市中国医学科学院血液学研究所工作。1986年9月回母校读研究生,师从著名外科学家王吉甫教授。1989年8月毕业,获医学硕士学位。1989年9月起在中山医科大学肿瘤医院腹科工作,1998年6月肝胆科成立后一直在肝胆科工作,其中1998.8-2001.8在美国进修学习。1991年晋升为主治医师,1997年晋升为副教授,2004年破格晋升为临床研究员,随后转聘为肿瘤外科教授、主任医师。

      主要从事肝癌的外科治疗和综合治疗环球体育平台登录(包括介入治疗、靶向治疗、免疫治疗等)。2003年9月开展肝移植治疗肝癌。肝移植的开展大大提高了肝外科的手术水平,肝切除术已无手术禁区。熟练掌握各种复杂的肝切除术(如巨大肝癌切除术、肝尾状叶切除术、扩大半肝切除术,中肝叶切除术等)等。临床工作认真负责,外科技术娴熟,手术精细。

    环球体育平台登录  在国内较早开展肝储备功能的研究,1992年开始应用吲哚靛青绿15分钟储留率(ICGR15)单一指标术前评估肝癌病人肝储备功能,明显降低了肝癌切除术后肝功能衰竭发生率[中华肿瘤杂志1995,17:377]。1997年首次提出对于不能切除的肝癌行肝动脉化疗栓塞,若肝储备功能良好,应使用较大剂量lipiodol栓塞,让lipiodol尽量填满肿瘤,达到肿瘤最大限度坏死,而不出现肝功能衰竭[癌症16:358和癌症16(增刊):39]。在国内较早提出ICGR15评估肝癌病人肝储备功能具有简便、实用、较准确等特点。

    环球体育平台登录  积极开展肝癌的临床研究,如肝癌的转化治疗,通过肝动脉栓塞灌注化疗(TACE+HAIC),联合免疫、靶向治疗等,使部分不可切除的肝癌转化为可手术切除。

      开展结直肠癌肝转移的外科治疗和临床研究,本医疗组每周参加结直肠癌的多学科会诊(Multi-Disciplinary Team, MDT)。本院结直肠癌肝转移的综合治疗在全国具有较好的声誉,本院大部分结直肠癌肝转移的外科治疗由本医疗组完成。积极参与国际交流,2012年7月在法国巴黎Paul Brousse医院学习结直肠癌肝转移的多学科治疗。

    环球体育平台登录  受国家卫生部推荐,于1998年获得世界卫生组织奖学金。作为访问学者,1998.9-2000.7在美国Baylor医学院进修,2000.8~2001.8在美国M.D. Anderson癌症中心进修。学习肿瘤分子生物学、肿瘤基因治疗与肝胆肿瘤的外科治疗等。国际上首次发现SYK基因的不表达是由其启动子过甲基化引起(Cancer Research 2001, 61:5558)。2001年8月回国后,继续开展肿瘤分子生物学的研究,医院给本课题组配备了独立的肝癌分子生物学实验室和研究助手,获得多项国家自然科学基金。作为(共同)第一或(共同)通讯作者,论文发表在The Journal of Clinical Oncology, The Journal of Clinical Investigation, Gastroenterology, Hepatology, Gut, Cancer Research, Clinical Cancer Research, Oncogene等国际知名杂志。

      精心培养研究生,已毕业的研究生留在本院工作,或录取到中山大学其他附属医院,或在广东、北京、湖南、江西等地三甲医院工作。其中洪健博士研究生获得2013年广东省优秀博士学位论文。


    部分科研基金:

    (1)  环球体育平台登录国家自然科学基金面上项目,S100A9通过EMT调控肝细胞癌侵袭转移的机制研究 ,项目负责人:元云飞,项目编号:81972301,经费(直接费用):55.00万元,2020.01~2023.12

    (2)  环球体育平台登录国家自然科学基金面上项目,Elafin通过EGFR/ERK信号通路调控肝细胞癌侵袭转移的机制研究,项目负责人:元云飞,项目编号:81772598,经费(直接费用):65万人民币,2018.01~2021.12。

    (3)  国家自然科学基金面上项目,Rfx6在肝癌干细胞干性特征维持中的作用及机制研究,项目负责人:元云飞,项目编号:81372571,经费:90万人民币,2014.01~2017.12。

    (4)  国家自然科学基金面上项目,肝癌Chk1/SYK(L)通路与靶向治疗,项目负责人:元云飞,项目编号:81172344,经费:69万人民币,2012.01~2015.12。

    (5)  国家自然科学基金面上项目,Chk1 参与肝癌Syk(L)和Syk(S)的表达调控及机制研究,项目负责人:元云飞,项目编号:30972916,经费:32万人民币,2010.01~2012.12。

    (6)  环球体育平台登录国家自然科学基金面上项目,SYK 作为肝癌复发转移标志物的研究,项目负责人:元云飞,项目编号:30872489,经费:30万人民币,2009.01~2011.12。

    (7)  国家自然科学基金专项基金项目(科学部主任基金),SYK 基因与肝细胞癌侵袭性的研究,项目负责人:元云飞,项目编号:30540047,经费:8万人民币,2006.01~2006.12。

    (8)  环球体育平台登录广东省自然科学基金重点项目,PI3基因抑制肝细胞癌侵袭转移的分子机制,项目编号: 2017A030311006,经费:50万人民币,2017.05~2020.05

    (9)  广州市科技计划项目重点项目专题, Rfx6促进肝细胞癌侵袭转移的机制研究,项目编号: 201804020093,经费: 200万人民币,2018.05~2021.04

    (10)国家重点基础研究发展计划(973计划),肿瘤异质性演化机制与个体治疗策略的生物学研究,项目首席科学家:吴仲义,分题骨干,经费:62.5万,2014.01~2018.12

    (11)环球体育平台登录中山大学临床医学研究5010计划项目,精准肝切除与综合介入治疗方案治疗肝细胞肝癌合并肝硬化门静脉高压症的临床随机对照研究,项目负责人:元云飞,经费:200 万人民币,2012 .07~2022.7

    (12)中山大学(985工程)转化医学研究示范性项目,早期肝癌复发转移相关DNA甲基化表型的筛选和预测体系的建立,项目负责人:元云飞,经费:100万人民币,2011~2013。

    (13)广东省高等学校科技创新重点项目(广东省教育厅),肝细胞肝癌合并肝硬化门静脉高压症的治疗策略,项目负责人:元云飞,项目编号:CXZD1133,经费:25万人民币,2012.1~2014.12。

    (14)985-II 工程项目课题,肝细胞癌肿瘤相关基因甲基化的研究,项目负责人:元云飞,经费:30万人民币,2006.1-2007.12

    (15)美国中华医学基金会(China Medical Board of New York, Inc.),“SYK gene methylation, SYK protein expression, and Hepatocellular carcinoma invasion.” 课题负责人(PI):元云飞, N 98-677, US$ 70 000,2003.1~2004.12.  

    (16)广东省科技厅科技计划项目,肿瘤侵袭性相关基因的过甲基化作为肝癌复发转移标志物的研究,项目负责人:元云飞,项目编号:2002B30107,经费:15万民币,2003.1~2005.12。


    部分论文:

    Peer-Reviewed Original Research Articles (* as correspondence author):

    2001-2007:

    (1)      Yunfei Yuan, Richard Mendez, Aysegul Sahin, and Jia Le Dai*. Hypermethylation leads to silencing of the SYK环球体育平台登录 gene in human breast cancer. Cancer Research 2001, 61(14):5558-5561. (2001 IF=8.302)

    (2)      Yunfei Yuan, Hongji Liu, Aysegul Sahin and Jia Le Dai*. Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness. International Journal of Cancer 2005, 113(4):654–659. (2005 IF=4.7)

    (3)      Yunfei Yuan*, Jianping Wang, Jinqing Li, Li Wang, Meixiang Li, Zuli Yang, Changqing Zhang, and Jia Le Dai.  Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular Carcinoma. Clinical Cancer Research 2006, 12(22):6687-6695. (2006 IF=6.177)

    (4)      Christina Pramudji, Satoru Shimura, Shin Ebara, Guang Yang, Jianxiang Wang, Chengzhen Ren, Yunfei Yuan环球体育平台登录, Salahaldin A. Tahir, Terry L. Timme, and Timothy C. Thompson*. In Situ Prostate Cancer Gene Therapy Using a Novel Adenoviral Vector Regulated by the Caveolin-1 Promoter. Clinical Cancer Research, 2001, 7(12):4272-4279.


    2008:

    (5)      Li Xu, Liang Huang, Bin-kui Li, Ya-qi Zhang, Jin-qing Li, Yun-fei Yuan*环球体育平台登录. Clinicopathologic Features and Long-Term Outcomes of Chinese Patients with Hepatocellular Carcinoma in Non-Cirrhotic Liver. Digestive Surgery 2008, 25(5):376. (2008 IF=1.257)

    (6)      Hang Su, Jing Zhao, Yujuan Xiong, Teng Xu, Fan Zhou, Yunfei Yuan环球体育平台登录, Ying Zhang, Shi-Mei Zhuang*. Large-scale analysis of the genetic and epigenetic alterations in hepatocellular carcinoma from Southeast China. Mutation Research 2008, 641:27-35.

    (7)      Xing-Dong Xiong, Jian-Hong Fang, Fu-En Qiu, Jing Zhao, Jiasen Cheng, Yunfei Yuan环球体育平台登录, Sheng-Ping Li, Shi-Mei Zhuang*. A novel functional polymorphism in the Cdc6 promoter is associated with the risk for hepatocellular carcinoma. Mutation Research, 2008, 643:70-74.

    (8)      Teng Xu, Ying Zhu, Qing-Kun Wei, Yunfei Yuan环球体育平台登录, Fan Zhou, Yi-Yuan Ge,JR Yang, H Su, Shi-Mei Zhuang*. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis 2008, 29(11):2126-2131.


    2009:

    (9)      Hang Su, Jian-Rong Yang, Teng Xu, Jun Huang, Li Xu, Yunfei Yuan*, Shi-Mei Zhuang*. MicroRNA-101, Downregulated in Hepatocellular Carcinoma, Promotes Apoptosis and Suppresses Tumorigenicity. Cancer Research 2009, 69(3):1135-42. (2009 IF=7.543)

    (10)  Jun Huang, Bin-Kui Li, Gui-Hua Chen, Jin-Qing Li, Ya-Qi Zhang, Guo-Hui Li, Yun-fei Yuan*. Long-Term Outcomes and Prognostic Factors of Elderly Patients with Hepatocellular Carcinoma Undergoing Hepatectomy. Journal of Gastrointestinal Surgery 2009, 13(9):1627-1635. (2009 IF=2.402)


    2010:

    (11)  Binkui Li, Wenji Liu, Li Wang, Meixiang Li, Jianping Wang, Liang Huang, Pinzhu Huang, and Yunfei Yuan环球体育平台登录*. CpG Island Methylator Phenotype Associated with Tumor Recurrence in Tumor-Node-Metastasis Stage I Hepatocellular Carcinoma. Annals of Surgical Oncology, 2010, 17(7):1917-1926. (2010 IF=4.182)

    (12)  Binkui Li, Yunfei Yuan*, Guihua Chen环球体育平台登录, Liru He, Yaqi Zhang, Jinqing Li, Guohui Li, and Wan Yee Lau. Application of tumor-node-metastasis staging 2002 version in locally advanced hepatocellular carcinoma: is it predictive of surgical outcome? BMC Cancer. 2010, 10:535-43. (2010 IF=3.153)

    (13)  Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, Dong Xie*. Liver Cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology, 2010, 51(2):535-544.

    (14)  Chunxian Zeng, Ruizhi Wang, Daochuan Li, Xue-Jia Lin, Qing-Kun Wei, Yunfei Yuan环球体育平台登录, Qing Wang, Wen Chen, and Shi-Mei Zhuang*. A Novel GSK-3 beta–C/EBP alpha–miR-122–Insulin-Like Growth Factor 1 Receptor Regulatory Circuitry in Human Hepatocellular Carcinoma. Hepatology 2010, 52:1702-1712.

    (15)  Leilei Chen, Tim Hon Man Chan, Yun-Fei Yuan环球体育平台登录, Liang Hu, Jun Huang, Stephanie Ma, Jian Wang, Sui-Sui Dong, Kwan Ho Tang, Dan Xie, Yan Li, and Xin-Yuan Guan*. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. The Journal of Clinical Investigation. 2010, 120(4):1178-91.

    (16)  Hongxing Zhang, Yun Zhai, Zhibin Hu, Chen Wu, Ji Qian, Weihua Jia, Fuchao Ma, Wenfeng Huang, Lixia Yu, Wei Yue, Zhifu Wang, Peiyao Li, Yang Zhang, Renxiang Liang, Zhongliang Wei, Ying Cui, Weimin Xie, Mi Cai, Xinsen Yu, Yunfei Yuan, Xia Xia, Xiumei Zhang, Hao Yang, Wei Qiu, Jingmin Yang, Feng Gong, Minshan Chen, Hongbing Shen, Dongxin Lin, Yi-Xin Zeng, Fuchu He* & Gangqiao Zhou*. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. 环球体育平台登录Nature Genetics. 2010, 42(9):755-8.

    (17)  Ming Shi, Ji-An Chen, Xiao-Jun Lin, Rong-Ping Guo, Yun-Fei Yuan环球体育平台登录, Min-Shan Chen, Ya-Qi Zhang, Jin-Qing Li*. Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China. World Journal of Gastroenterology 2010, 16(2): 264-269.

    (18)  Guo-Liang Huang, Bin-Kui Li, Mei-Yin Zhang, Hui-Zhong Zhang, Rong-Rong Wei, Yun-Fei Yuan环球体育平台登录, Ming Shi, Xiao-Qian Chen, Long Huang, An-Hua Li, Bi-Jun Huang, Hong-Hua Li, Hui-Yun Wang*. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. World Journal of Gastroenterology 2010, 16(16): 2046-2054.


    2011:

    (19)  Liang Huang, Mei-Xiang Li, Li Wang, Bin-Kui Li, Gui-Hua Chen, Li-Ru He, Li Xu, Yun-Fei Yuan*. Prognostic value of Wnt inhibitory factor-1 expression in hepatocellular carcinoma that is independent of gene methylation. Tumor Biology 2011, 32:233-240. 环球体育平台登录(2011 IF=2.143)

    (20)  Leilei Chen, Yun-Fei Yuan(co-first), Yan Li, Tim Hon Man Chan, Bo-Jian Zheng, Jun Huang, Xin-Yuan Guan*. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut 2011, 60(4):534-43. (2011 IF=10.111)

    (21)  Pinzhu Huang, Jiliang Qiu, Binkui Li, Jian Hong, Canliang Lu, Li Wang, Jianping Wang, Yezhu Hu, Weihua Jia, Yunfei Yuan*. Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. Clinical Biochemistry 2011, 44:582-589. (2011 IF=2.076)

    (22)  Jiliang Qiu, Pinzhu Huang, Qian Liu, Jian Hong, Binkui Li, Canliang Lu, Li Wang, Jianping Wang and Yunfei Yuan*环球体育平台登录. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. Journal of Translational Medicine 2011, 9:166. (2011 IF=3.474)

    (23)  Can-Liang Lu, Ji-Liang Qiu, Pin-Zhu Huang, Ru-Hai Zou, Jian Hong, Bin-Kui Li, Gui-Hua Chen, Yunfei Yuan*. NADPH Oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy. Tumor Biology 2011, 32(6):1173-1182. (2011 IF=2.143)

    (24)  Jian Li, George Ka-Kit Lau, Leilei Chen, Sui-sui Dong, Hui-Yao Lan, Xiao-Ru Huang, Yan Li, John M. Luk, Yun-Fei Yuan, Xin-yuan Guan*. Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression. PLoS ONE 2011, 6(7): e21816.

    (25)  Xiang-Ming Lao, Dian Wang, Ming Shi, Guipeng Liu, Shengping Li, Rongping Guo, Yunfei Yuan, Minshan Chen, Jinqing Li, Yaqi Zhang* and Xiaojun Lin*. Changes in hepatitis B virus DNA levels and liver function after transcatheter arterial chemoembolization of hepatocellular carcinoma. Hepatology Research 2011, 41(6): 553-563.

    (26)  Qian Zhou, Arthur K.-K. Ching, Wilson K.-C. Leung, Carol Y.-Y. Szeto, Shuk-Mei Ho, Paul K.-S. Chan, Yun-Fei Yuan, Paul B.-S. Lai, Winnie Yeo, Nathalie Wong*. Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma. International Journal of Oncology 2011, 38(3):721-731.


    2012:

    (27)  Jian Hong, Kaishun Hu, Yunfei Yuan*, Yi Sang, Qiangui Bu, Guihua Chen, Longjun Yang, Binkui Li, Pinzhu Huang, Dongtai Chen, Yi Liang, Ruhua Zhang, Jingxuan Pan, Yi-Xin Zeng, and Tiebang Kang*. CHK1 targets spleen tyrosine kinase(L) for proteolysis in hepatocellular carcinoma. The Journal of Clinical Investigation 2012, 122(6):2165-2175. (2012 IF=12.812)

    (28)  Qing-an Zeng, Jiliang Qiu, Jian Hong, Yi Li, Shengping Li, Ruhai Zou, Pinzhu Huang, Binkui Li, Yun Zheng, Xiangming Lao and Yunfei Yuan*. Hepatectomy for hepatocellular carcinoma patients with macronodular cirrhosis. European Journal of Gastroenterology & Hepatology. 2012, 24(5):575-82. (2012 IF=1.915)

    (29)  Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao, Yunfei Yuan环球体育平台登录*. Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study. BMC Cancer 2012, 12(1):148. (2012 IF=3.333)

    (30)  Ru-hai Zou, An-hua Li, Feng Han, Jiang Hong, Bin-kui Li, Wei Huang, Liang Huang, Yun-fei Yuan环球体育平台登录*. Liver hypertrophy and accelerated growth of implanted tumors in nonembolized liver of rabbit after left portal vein embolization. Journal of Surgical Research 2012, 178:256-263 (online Apr 2, 2012) (2012 IF=2.018)

    (31)  Ji-Liang Qiu, Pin-Zhu Huang, Jing-Hong You, Ru-Hai Zou, Li Wang, Jian Hong, Bin-Kui Li, Kai Zhou, and Yun-fei Yuan*. LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy. Chinese Journal of Cancer 2012, 31(5):223-232. (2014, IF=2.155)

    (32)  Dongtai Chen, Wei Xing, Jian Hong, Meibing Wang, Yang Huang, Cuizhen Zhu, Yunfei Yuan, and Weian Zeng*. The Beta2-adrenergic receptor is a potential prognostic biomarker for human hepatocellular carcinoma after curative resection. Annals of Surgical Oncology 2012, 19:3556–3565

    (33)  Pengyuan Yang, Qi-Jing Li, Yuxiong Feng, Yun Zhang, Geoffrey J. Markowitz,  Shanglei Ning, Yuezhen Deng, Jiangsha Zhao, Shan Jiang, Yunfei Yuan环球体育平台登录, Hong-Yang Wang, Shu-Qun Cheng, Dong Xie*, and Xiao-Fan Wang*. TGF-b-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Cancer Cell. 2012, 22(3), 291–303,

    (34)  Pinzhu Huang, Jiliang Qiu, Jinghong You, Jian Hong, Binkui Li, Kai Zhou, Guihua Chen, Yunfei Yuan, and Ruhai Zou*. Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues. Biomarkers. 2012, 17(5):422-9.

    (35)  Tim Hon Man Chan, Leilei Chen, Ming Liu, Liang Hu, Bo-jian Zheng, Vincent Kwok-Man Poon, Pinzhu Huang, Yun-Fei Yuan, Jian-dong Huang, Jie Yang, George Sai-wah Tsao, and Xin-Yuan Guan*. Translationally Controlled Tumor Protein Induces Mitotic Defects and Chromosome Missegregation in Hepatocellular Carcinoma Development. Hepatology 2012, 55:491-505

    (36)  Ming Liu, Leilei Chen, Tim Hon Man Chan, Jian Wang, Yan Li, Yan Li, Ting-Ting Zeng, Yun-Fei Yuan, and Xin-Yuan Guan*. Serum and Glucocorticoid Kinase 3 at 8q13.1 Promotes Cell Proliferation and Survival in Hepatocellular Carcinoma. Hepatology 2012, 55:1754-1765

    (37)  Guo-Liang Huang, Bin-Kui Li, Mei-Yin Zhang, Rong-Rong Wei, Yun-Fei Yuan环球体育平台登录, Ming Shi, Xiao-Qian Chen, Long Huang, Hui-Zhong Zhang, Wanqing Liu, Bi-Jun Huang, Honghua Li, Xiao-Feng Zheng, Xian-Rong Luo, Hui-Yun Wang*. Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma. PLoS ONE 2012, 7(8): e44061.

    (38)  Chan Xie, Li-bing Song, Jue-heng Wu, Jun Li, Jing-ping Yun, Jia-ming Lai, Dong-ying Xie, Bingliang Lin, Yun-fei Yuan, Mengfeng Li*, Zhi-liang Gao*. Upregulator of Cell Proliferation Predicts Poor Prognosis in Hepatocellular Carcinoma and Contributes to Hepatocarcinogenesis by Downregulating FOXO3a . PLoS ONE 2012, 7(7): e40607

    (39)  Jian Li, George Lau, Leilei Chen, Yun-Fei Yuan环球体育平台登录, Jun Huang, John M. Luk, Dan Xie, Xin-Yuan Guan*. Interleukin 23 Promotes Hepatocellular Carcinoma Metastasis via NF-Kappa B Induced Matrix Metalloproteinase 9 Expression. PLoS ONE 2012, 7(9): e46264.


    2013:

    (40)  Yan Li, Leilei Chen, Tim Hon Man Chan, Ming Liu, Kar–Lok Kong, Ji–Liang Qiu, Yan Li, Yun–Fei Yuan*, and Xin–Yuan Guan*. SPOCK1 Is Regulated by CHD1L and Blocks Apoptosis and Promotes HCC Cell Invasiveness and Metastasis in Mice. Gastroenterology 2013, 144:179-191 (Epub 2012 Sep 25) (2013 IF=13.926)

    (41)  J.-L. Qiu, M.-G. Deng, W Li, R.-H. Zou, B.-K. Li, Y Zheng, X.-M. Lao, K Zhou, Y.-F. Yuan*. Hepatic Resection for Synchronous Hepatic Metastasis from Gastric Cancer. European Journal of Surgical Oncology 2013, 39:694-700 (2013 IF=2.843)

    (42)  Ruizhi Wang, Na Zhao, Siwen Li, Jian-Hong Fang, Mei-Xian Chen, Jine Yang, Wei-Hua Jia, Yunfei Yuan* and Shi-Mei Zhuang*. MicroRNA-195 Suppresses Angiogenesis and Metastasis of Hepatocellular Carcinoma by Inhibiting the Expression of VEGF, VAV2, and CDC42. Hepatology 2013, 58(2):642-53. (2013 IF=11.19)

    (43)  J Gong, J-P Zhang, B Li, C Zeng, K You, M-X Chen, Y Yuan环球体育平台登录* and S-M Zhuang*. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene 2013, 32(25):3071-9. (2013 IF=8.559)

    (44)  Rongrong Wei, Guo-Liang Huang, Mei-Yin Zhang, Bin-Kui Li, Hui-Zhong Zhang, Ming Shi, Xiao-Qian, Chen, Long Huang, Qing-Ming Zhou, Wei-Hua Jia, X.F. Steven Zheng, Yun-Fei Yuan*, and Hui-Yun Wang*. Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma. Clinical Cancer Research 2013, 19(17): 1-12. (2013 IF=8.193)

    (45)  Chan Xie, Jueheng Wu, Jingping Yun, Jiaming Lai, Yunfei Yuan, Zhiliang Gao, Mengfeng Li, Jun Li, Libing Song*. MACC1 as a Prognostic Biomarker for Early-Stage and AFP-Normal Hepatocellular Carcinoma. PLoS ONE 2013, 8(5): e64235.

    (46)  Leilei Chen, Yan Li, Chi Ho Lin, Tim Hon Man Chan1, Raymond Kwok Kei Chow, Yangyang Song, Ming Liu, Yun-Fei Yuan环球体育平台登录, Li Fu, Kar Lok Kong, Lihua Qi, Yan Li, Na Zhang, Amy Hin Yan Tong, Dora Lai-Wan Kwong, Kwan Man, Chung Mau Lo, Si Lok, Daniel G Tenen* & Xin-Yuan Guan*. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nature Medicine 2013, 19(2):209-16.

    (47)  Qiang Gong, Yong Tao, Jian-Rong Yang, Jun Cai, Yunfei Yuan, Jue Ruan, Jin Yang, Hailiang Liu, Wanghua Li, Xuemei Lu, Shi-Mei Zhuang, San Ming Wang and Chung-I Wu. Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC Genomics. 2013, 24;14:51.

    (48)  Song Ling Poon, See-Tong Pang, John R. McPherson, Willie Yu,  Kie Kyon Huang, Peiyong Guan, Wen-Hui Weng, Ee Yan Siew, Yujing Liu, Hong Lee Heng, Soo Ching Chong, Anna Gan, Su Ting Tay, Weng Khong Lim, Ioana Cutcutache, Dachuan Huang, Lian Dee Ler, Maarja-Liisa Nairismägi, Ming Hui Lee, Ying-Hsu Chang, Kai-Jie Yu, Waraporn Chan-on, Bin-Kui Li, Yun-Fei Yuan, Chao-Nan Qian, Kwai-Fong Ng, Ching-Fang Wu, Cheng-Lung Hsu, Ralph M. Bunte, Michael R. Stratton, P. Andrew Futreal, Wing-Kin Sung, Cheng-Keng Chuang, Choon Kiat Ong, Steven G. Rozen, Patrick Tan, Bin Tean Teh.  Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool.   Science Translational Medicine 2013, 5:197ra101;

    (49)  Zuli Yang, Lijun Huo, Hao Chen, Beibei Ni, Jun Xiang, Liang Kang, Lei Wang, Junsheng Peng, Yunfei Yuan环球体育平台登录, Jianping Wang*. Hypermethylation and prognostic implication of Syk gene in human colorectal cancer. Medical Oncology 2013, 30(2):586.

    (50)  Yingjun Liu, Shengping Li, Xiangbin Wan, Yi Li, Binkui Li, Yaqi Zhang, Yunfei Yuan and Yun Zheng*. Efficacy and safety of thermal ablation in patients with liver metastases. European Journal of Gastroenterology & Hepatology. 2013, 25(4):442-6.

    (51)  Xiang-Ming Lao, Guangyu Luo, Liang-Tao Ye, Cheng Luo, Ming Shi, Dian Wang, Rongping Guo, Minshan Chen, Shengping Li*, Xiaojun Lin and Yunfei Yuan. Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma. Liver International. 2013, 33(4):595-604.

    (52) Yongdong Dai, Lulu Liu, Tingting Zeng, Ying-Hui Zhu, Jiangchao Li, Leilei Chen, Yan Li, Yun-Fei Yuan, Stephanie Ma, Xin-Yuan Guan. Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 2013, 436(4):711-8.

    (53) Ru-Hai Zou, Qi-Jiong Li, Ji-Liang Qiu, Ya-Di Liao, Yun-Fei Yuan, An-Hua Li. A modified radiofrequency ablation approach for treating distant lymph node metastasis in two patients with late-stage cancer. Chinese Journal of Cancer. 2013, 32(10):567-70.

    (54) Ruizhi Wang, Na Zhao, Siwen Li, Jian-Hong Fang, Mei-Xian Chen, Jine Yang, Wei-Hua Jia, Yunfei Yuan, Shi-Mei Zhuang. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology. 2013, 58(2):642-53.


    2014:

    (55)  Jian Hong, Yunfei Yuan*, Jianping Wang, Yadi Liao, Ruhai Zou, Chuanlong Zhu, Binkui Li, Yi Liang, Pinzhu Huang, Zongwei Wang, Wenyu Lin, Yixin Zeng, Jia Le Dai, and Raymond T. Chung*. Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma. Cancer Research 2014, 74(6):1845-56 (2014 IF=9.329)

    (56)  Binkui Li, Pinzhu Huang, Jiliang Qiu, Yadi Liao, Jian Hong, Yunfei Yuan*. MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis. Medical Oncology, 2014, 31(10): 230. (2014 IF=2.634)

    (57)  Jun Huang, Qijiong Li, Yun Zheng, Jingxian Shen, Jiliang Qiu, Binkui Li, Ruhai Zou, Jianping Wang and Yunfei Yuan*. Partial hepatectomy for liver metastases from nasopharyngeal carcinoma: a comparative study and review of the literature. BMC Cancer 2014, 14:818. (2014 IF=3.362)

    (58)  Bin-Kui Li, Pin-Zhu Huang, Ji-Liang Qiu, Ya-Di Liao, Jian Hong and Yun-Fei Yuan环球体育平台登录*. Upregulation of microRNA-106b is associated with poor prognosis in hepatocellular carcinoma. Diagnostic Pathology 2014, 9:226.(2014 IF=2.597)

    (59) Cong Li, Yangkui Gu, Ming Zhao, Yunfei Yuan环球体育平台登录, Fenghua Wang, Zhiqiang Wang, Wang Li, Huiyan Luo, Cui Chen, Gong Chen, Peirong Ding, Xiaojun Wu, Zhenhai Lu, Zhizhong Pan, Ruihua Xu, Youjian He, Desen Wan, Yuhong Li. Phase I trial of hepatic arterial infusion (HAI) of floxuridine with modified oxaliplatin, 5-fluorouracil and leucovorin (m-FOLFOX6) in Chinese patients with unresectable liver metastases from colorectal cancer. Cancer chemotherapy and pharmacology. 2014, 4(5):1079-87.

    (60) Stella Chai, Man Tong, Kai Yu Ng, Pak Shing Kwan, Yuen Piu Chan, Tsun Ming Fung, Terence K Lee, Nathalie Wong, Dan Xie, Yun-Fei Yuan, Xin-Yuan Guan, Stephanie Ma. Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. Oncotarget. 2014, 5(14):5725-35.

    (61) Longhui Cao, Yi Chang, Wenqian Lin, Jianhua Zhou, Hongying Tan, Yunfei Yuan环球体育平台登录, Weian Zeng. Long-term survival after resection of hepatocelluar carcinoma: a potential risk associated with the choice of postoperative analgesia. Anesthesia & Analgesia. 2014, 118(6):1309-16.

    (62) Yin Xie, Rong-Rong Wei, Guo-Liang Huang, Mei-Yin Zhang, Yun-Fei Yuan环球体育平台登录, Hui-Yun Wang. Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma. Medical Oncology. 2014, 31(3):844.

    (63) Ming Liu, Yan Li, Leilei Chen, Tim Hon Man Chan, Yangyang Song, Li Fu, Ting-Ting Zeng, Yong-Dong Dai, Ying-Hui Zhu, Juan Chen, Yun-Fei Yuan, Xin-Yuan Guan. Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma. Gastroenterology. 2014, 146(4):1084-96.

    (64) Lulu Liu, Yongdong Dai, Jinna Chen, Tingting Zeng, Yan Li, Leilei Chen, Ying-Hui Zhu, Jiangchao Li, Stephanie Ma, Dan Xie, Yun-Fei Yuan环球体育平台登录, Xin-Yuan Guan. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling. Hepatology. 2014, 59(2):531-43.

    (65) Tim Hon Man Chan, Chi Ho Lin, Lihua Qi, Jing Fei, Yan Li, Kol Jia Yong, Ming Liu, Yangyang Song, Raymond Kwok Kei Chow, Vanessa Hui En Ng, Yun-Fei Yuan, Daniel G Tenen, Xin-Yuan Guan, Leilei Chen. A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut. 2014, 63(5):832-43.


    2015:

    (66)  Wei He, Qingli Zeng, Yun Zheng, Meixian Chen, Jingxian Shen, Jiliang Qiu, Miao Chen,  Ruhai Zou, Yadi Liao, Qijiong Li, Xianqiu Wu, Binkui Li* and Yun-Fei Yuan环球体育平台登录*. The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis. BMC Cancer 2015, 15:263. (2015 IF=3.265)

    (67)  Xianqiu Wu, Binkui Li, Jiliang Qiu, Jingxian Shen, Yun Zheng, Qijong Li, Yadi Liao, Wei He, Ruhai Zou and Yunfei Yuan环球体育平台登录*. Hepatectomy versus hepatectomy with lymphadenectomy in hepatocellular carcinoma – A prospective, randomized controlled clinical trial. Journal of Clinical Gastroenterology 2015;49:520-528(2015 IF=3.163)

    (68)  Jiliang Qiu, Yun Zheng, Jingxian Shen, Zeng QingAn, Ruhai Zou, Yadi Liao, Wei He, Qijiong Li, Guihua Chen, Binkui Li, Yunfei Yuan*. Resection versus ablation in hepatitis B virus-related hepatocellular carcinoma patients with portal hypertension: A propensity score matching study. Surgery. 2015, 158(5):1235-1243.(2015 IF=3.309)

    (69) Lingxi Jiang, Dora Lai-Wan Kwong, Yan Li, Ming Liu, Yun-Fei Yuan环球体育平台登录, Li Fu, Xin-Yuan Guan*. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Carcinogenesis. 2015, 36(10):1111-20.

    (70) Yangyang Song, Guangjin Pan, Leilei Chen, Stephanie Ma, Tingting Zeng, Tim Hon Man Chan, Lei Li, Qizhou Lian, Raymond Chow, Xiujuan Cai, Yan Li, Ming Liu, Yun Li, Yinghui Zhu, Nathalie Wong, Yun-Fei Yuan环球体育平台登录, Duanqing Pei, Xin-Yuan Guan*. Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells. Gastroenterology. 2015, 149(4):1068-81.

    (71) Man Tong, Tsun-Ming Fung, Steve T Luk, Kai-Yu Ng, Terence K Lee, Chi-Ho Lin, Judy W Yam, Kwok Wah Chan, Fai Ng, Bo-Jian Zheng, Yun-Fei Yuan环球体育平台登录, Dan Xie, Chung-Mau Lo, Kwan Man, Xin-Yuan Guan, Stephanie Ma. ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma. Stem Cell Reports. 2015, 5(1):45-59.

    (72) Xue-Jia Lin, Yutian Chong, Zhi-Wei Guo, Chen Xie, Xiao-Jing Yang, Qi Zhang, Sheng-Ping Li, Yujuan Xiong, Yunfei Yuan环球体育平台登录, Jun Min, Wei-Hua Jia, Yusheng Jie, Min-Shan Chen, Mei-Xian Chen, Jian-Hong Fang, Chunxian Zeng, Yaojun Zhang, Rong-Ping Guo, Yuankai Wu, Guoli Lin, Limin Zheng, Shi-Mei Zhuang. A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study. The Lancet Oncology. 2015, 16(7):804-15.

    (73) Zhong-Guo Zhou, Xing-Rong Zheng, Qian Zhou, Ming Shi, Yao-Jun Zhang, Rong-Ping Guo, Yun-Fei Yuan, Min-Shan Chen, Xiao-Jun Lin, Xiang-Ming Lao, Sheng-Ping Li. Impact of oral anti-hepatitis B therapy on the survival of patients with hepatocellular carcinoma initially treated with chemoembolization. Chinese Journal of Cancer. 2015, 34(5):205-16.

    (74) Jian-Hong Fang, Hui-Chao Zhou, Chong Zhang, Li-Ru Shang, Lei Zhang, Jing Xu, Limin Zheng, Yunfei Yuan, Rong-Ping Guo, Wei-Hua Jia, Jing-Ping Yun, Min-Shan Chen, Yaojun Zhang, Shi-Mei Zhuang. A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial-mesenchymal transition-independent manner. Hepatology. 2015, 62(2):452-65.

    (75) Fang Zheng, Yi-Ji Liao, Mu-Yan Cai, Tian-Hao Liu, Shu-Peng Chen, Pei-Hong Wu, Long Wu, Xiu-Wu Bian, Xin-Yuan Guan, Yi-Xin Zeng, Yun-Fei Yuan, Hsiang-Fu Kung, Dan Xie. Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets. PLoS Genetics. 2015, 11(2):e1004873.

    (76)  Jian Wang, Ming Liu, Leilei Chen, Tim Hon Man Chan, Lingxi Jiang, Yun-Fei Yuan, Xin-Yuan Guan. Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility. Oncotarget. 2015, 6(3):1618-30.

    (77) Sheng-Long Ye*, Xiaoping Chen, Jiamei Yang, Ping Bie, Shuijun Zhang, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima, Christina SM YIP, Zhengguang Lu. Safety and efficacy of sorafenib therapy in patients with hepatocellular carcinoma: final outcome from the Chinese patient subset of the GIDEON study. Oncotarget. 2015, 7(6):6639


    2016:

    (78)  Pinghua Yang, Jiliang Qiu, Jun Li, Dong Wu, Xuying Wan, Wan Yee Lau, Yunfei Yuan*, and Feng Shen*. Nomograms for Pre- and Postoperative Prediction of Long-term Survival for Patients Who Underwent Hepatectomy for Multiple Hepatocellular Carcinomas. Annals of Surgery. 2016, 263(4):778-86. (2016 IF=8.98) 

    (79) Pinzhu Huang, Chunhong Liu,  Binkui Li,  Yun Zheng,  Ruhai Zou, Jun Huang,  Zemin Hu, Yunfei Yuan*. Preoperative mean corpuscular hemoglobin affecting long‑term outcomes of hepatectomized patients with hepatocellular carcinoma. Molecular and Clinical Oncology 2016, 4: 229-236.

    (80)  Wei He, Binkui Li, Yun Zheng, Ruhai Zou, Meixian Chen, Jingxian Shen, Donghui Cheng, Qiang Tao, Wenwu Liu, Qijiong Li, Guihua Chen and Yunfei Yuan*. Resection vs. ablation for alpha-fetoprotein positive hepatocellular carcinoma within the Milan criteria: a propensity score analysis. Liver International 2016, 36(11):1677-1687(2016 IF=4.116)

    (81)  Yunfei Yuan*, Wei He, Binkui Li. Liver Int. 2016 36(12):1878. (letter to the editor)

    (82)  Stella Chai, Kai-Yu Ng, Man Tong, Eunice Y. Lau, Terence K. Lee, Kwok Wah Chan, Yun-Fei Yuan环球体育平台登录, Tan-To Cheung, Siu-Tim Cheung, Xiao-Qi Wang, Nathalie Wong, Chung-Mau Lo, Kwan Man, Xin-Yuan Guan, and Stephanie Ma. Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells. Hepatology. 2016, 64(6):2062-2076.

    (83)  Hui-Chao Zhou, Jian-Hong Fang, Li-Ru Shang, Zi-Jun Zhang, Ye Sang, Li Xu, Yunfei Yuan环球体育平台登录, Min-Shan Chen, Limin Zheng, Yaojun Zhang and Shi-Mei Zhuang. MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. Journal of Pathology 2016, 240(4):450-460.

    (84)  Zhenhai Lu, Jianhong Peng, Zhiqiang Wang, Zhizhong Pan, Yunfei Yuan环球体育平台登录, Desen Wan Binkui Li. High preoperative serum CA19-9 level is predictive of poor prognosis for patients with colorectal liver oligometastases undergoing hepatic resection. Med Oncol. 2016, 33(11):121.

    (85)  Zhen-Hai Lu, Jian-Hong Peng, Fu-Long Wang, Yun-Fei Yuan, Wu Jiang, Yu-Hong Li,  Xiao-Jun Wu, Gong Chen, Pei-Rong Ding, Li-Ren Li. Ling-Heng Kong, Jun-Zhong Lin, Rong-Xin Zhang, De-Sen Wan, Zhi-Zhong Pan. Bevacizumab with preoperative chemotherapy versus preoperative chemotherapy alone for colorectal cancer liver metastases: a retrospective cohort study. Medicine (Baltimore). 2016 Aug;95(35):e4767.

    (86)  Ming Liu, Leilei Chen, Ning-Fang Ma, Raymond Kwok Kei Chow, Yan Li, Yangyang Song, Tim Hon Man Chan, Shuo Fang, Xiaodong Yang, Shaoyan Xi, Lingxi Jiang, Yun Li, Ting-Ting Zeng, Yan Li, Yun-Fei Yuan, and Xin-Yuan Guan. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 2016 May;63(5):1544-59.

    (87)  Sheng-Long Ye*, Xiaoping Chen, Jiamei Yang, Ping Bie, Shuijun Zhang, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan环球体育平台登录, Zhiren Fu, Keiko Nakajima, Christina S.M. Yip, Zhengguang Lu. Safety and efficacy of sorafenib therapy in patients with hepatocellular carcinoma: final outcome from the Chinese patient subset of the GIDEON study. Oncotarget. 2016 Feb 9;7(6):6639-48.


    2017:

    (88)  Jiliang Qiu, Baogang Peng, Yunqiang Tang, Yeben Qian, Pi Guo, Mengfeng Li, Junhang Luo, Bin Chen, Hui Tang, Canliang Lu, Muyan Cai, Zunfu Ke, Wei He, Yun Zheng, Dan Xie, Binkui Li*, and Yunfei Yuan*环球体育平台登录. A CpG Methylation Signature Predicts Recurrence in Early-Stage Hepatocellular Carcinoma: Results From a Multicenter Study. Journal of Clinical Oncology 2017, 35(7):734-742  (2017 IF=26.303)

    (89)  Yunfei Yuan*, Binkui Li, Jiliang Qiu. (reply to A. Braillon)  J Clin Oncol. 2017, 35(18):2098-2099

    (90)  Yadi Liao, Yun Zheng, Wei He, Qijiong Li, Jingxian Shen, Jian Hong, Ruhai Zou, Jiliang Qiu, Binkui Li* , Yunfei Yuan环球体育平台登录*. Sorafenib therapy following resection prolongs disease‑free survival in patients with advanced hepatocellular carcinoma at a high risk of recurrence.  Oncology Letters 2017, 13: 984-992. (2017 IF=1.664)

    (91)  Binkui Li*, Liru He, Dinglan Zuo, Wei He, Yongjin Wang, Yuanping Zhang, Wenwu Liu and Yunfei Yuan*环球体育平台登录. Mutual Regulation of MiR-199a-5p and HIF-1αModulates the Warburg Effect in Hepatocellular Carcinoma. Journal of Cancer 2017, 8:940-949. (2017 IF=3.249)

    (92)  Dong-liang Chen, Yun-xin Lu, Jia-xing Zhang, Xiao-li Wei, Feng Wang, Zhao-lei Zeng, Zhi-zhong Pan, Yun-fei Yuan, Feng-hua Wang, Helene Pelicano, Paul J. Chiao, Peng Huang, Dan Xie, Yu-hong Li, Huai-qiang Ju*, Rui-hua Xu*. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Theranostics 2017, 7(19), 4836–4849.

    (93)  You-Fang Chen, Jing-Dun Xie, Yu-Chuan Jiang, Dong-Tai Chen, Jia-Hao Pan, Yong-Hua Chen, Yun-Fei Yuan环球体育平台登录, Zhe-Sheng Wen*, Wei-An Zeng*. The Prognostic Value of Peripheral Benzodiazepine Receptor in Patients with Esophageal Squamous Cell Carcinoma. Journal of Cancer 2017, 8(16), 3343–3355.

    (94)  Yun Wang, Yun‑Fei Yuan, Hao‑Cheng Lin, Bin‑Kui Li, Feng‑Hua Wang, Zhi‑Qiang Wang, Pei‑Rong Ding, Gong Chen, Xiao‑Jun Wu, Zhen‑Hai Lu, Zhi‑Zhong Pan, De‑Sen Wan, Peng Sun, Shu‑Mei Yan, Rui‑Hua Xu* and Yu‑Hong Li*. Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases. Chin J Cancer 2017, 36:78.

    (95)  Yun Wang, Zhi-qiang Wang, Feng-hua Wang, Yun-fei Yuan环球体育平台登录, Bin-kui Li, Pei-rong Ding, Gong Chen, Xiao-jun Wu, Zhen-hai Lu, Zhi-zhong Pan, De-sen Wan, Peng Sun, Shu-mei Yan, Rui-hua Xu*, Yu-hong Li*. The Role of Adjuvant Chemotherapy for Colorectal Liver Metastasectomy after Pre-Operative Chemotherapy: Is the Treatment Worthwhile? J Cancer. 2017, 8(7):1179-1186

    (96)  Lingxi Jiang, Qian Yan, Shuo Fang, Ming Liu, Yan Li, Yun-Fei Yuan, Yan Li, Yinghui Zhu, Jiali Qi, Xiaodong Yang, Dora Lai Wan Kwong, Xin-Yuan Guan*. Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway. Hepatology 2017, 66(5), 1529–1545.

    (97)  Wei Xing, Dong-Tai Chen, Jia-Hao Pan, Yong-Hua Chen, Yan Yan, Qiang Li, Rui-Feng Xue, Yun-Fei Yuan环球体育平台登录, Wei-An Zeng*, Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo. Anesthesiology 2017, 126(5), 868–881

    (98)  Qian Yan, Lingxi Jiang, Ming Liu, Dandan Yu, Yu Zhang, Yan Li, Shuo Fang, Yan Li, Ying-Hui Zhu, Yun-Fei Yuan, Xin-Yuan Guan*. ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. Cancer Res. 2017,77(21):5831-5845.

    (99)  Jianhong Peng, Hui Li, Qingjian Ou, Junzhong Lin, Xiaojun Wu, Zhenhai Lu, Yunfei Yuan, Desen Wan, Yujing Fang*, Zhizhong Pan*. Preoperative lymphocyte-to-monocyte ratio represents a superior predictor compared with neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios for colorectal liver-only metastases survival. Onco Targets Ther. 2017,10:3789-3799. 

    (100)      Kai-Yu Ng, Lok-Hei Chan, Stella Chai, Man Tong, Xin-Yuan Guan, Nikki P Lee, Yunfei Yuan, Dan Xie, Terence K Lee, Nelson J Dusetti, Alice Carrier, Stephanie Ma*. Cancer Res. 2017, 77(17):4602-4612


    2018:

    (101)      Wei He, Baogang Peng, Yunqiang Tang, Junpin Yang, Yun Zheng, Jiliang Qiu, Ruhai Zou, Jingxian Shen, Binkui Li*, Yunfei Yuan*. Nomogram to Predict Survival of Patients with Recurrence of Hepatocellular Carcinoma After Surgery. Clinical Gastroenterology and Hepatology 2018;16:756–764  (2018 IF=7.958)

    (102)      Wei He, Yun Zheng, Ruhai Zou, Jingxian Shen, Junpin Yang, Jiliang Qiu, Qiang Tao, Wenwu Liu, Zhiwen Yang, Yuanping Zhang, Binkui Li*, Yunfei Yuan环球体育平台登录*.  Cancer Communications (Lond). 2018, 38(1):26. (2018 IF=3.620)

    (103)      Qiang Tao, Wei He, Binkui Li, Yun Zheng,, Ruhai Zou, Jingxian Shen, Wenwu Liu, Yuanping Zhang, Yunfei Yuan环球体育平台登录*. Resection versus Resection with Preoperative Transcatheter Arterial Chemoembolization for Resectable Hepatocellular Carcinoma Recurrence. Journal of Cancer 2018, 9(16), 2778–2785. (2018 IF=3.182)

    (104)      Zhi-Wen Yang, Wei He, Yun Zheng, Ru-Hai Zou, Wen-Wu Liu, Yuan-Ping Zhang, Chen-Wei Wang, Yong-Jin Wang, Yi-Chuan Yuan, Bin-Kui Li*, Yun-Fei Yuan环球体育平台登录*. The efficacy and safety of long- versus short-interval transarterial chemoembolization in unresectable hepatocellular carcinoma. Journal of Cancer. 2018, 9(21):4000-4008. (2018 IF=3.182)

    (105)      Wenwu Liu, Yun Zheng, Wei He, Ruhai Zou, Jiliang Qiu, Jingxian Shen, Zhiwen Yang, Yuanping Zhang, Chenwei Wang, Yongjin Wang, Dinglan Zuo, Binkui Li*, Yunfei Yuan*. Microwave vs radiofrequency ablation for hepatocellular carcinoma within the Milan criteria: a propensity score analysis. Alimentary Pharmacology & Therapeutics 2018, 48(6):671-681. (2018 IF=7.731)

    (106)      Wenwu Liu, Binkui Li, Yunfei Yuan环球体育平台登录*.  Alimentary Pharmacology & Therapeutics. 2018, 48(9):1027-1028

    (107)      Wenwu Liu, Binkui Li, Yunfei Yuan环球体育平台登录*.  Alimentary Pharmacology & Therapeutics. 2018,48(11-12):1326-1327.

    (108)      Wenwu Liu, Yun Zheng, Ruhai Zou, Jingxian Shen, Wei He, Zhiwen Yang, Yuanping Zhang, Binkui Li* and Yunfei Yuan*. Impact of follow-up interval on patients with hepatocellular carcinoma after curative ablation. BMC Cancer 2018, 18:1186 (2018 IF=2.933)

    (109)      Jian-Hong Fang*, Zi-Jun Zhang, Li-Ru Shang, Yu-Wei Luo, Yi-Fang Lin, Yunfei Yuan*, and Shi-Mei Zhuang*.  Hepatology. 2018, 68(4):1459-1475.  (2018 IF=14.971)

    (110)      Kai You, Song-Yang Li, Jiao Gong, Jian-Hong Fang, Chong Zhang, Min Zhang, Yunfei Yuan环球体育平台登录, Jine Yang*, and Shi-Mei Zhuang*. MicroRNA-125b Promotes Hepatic Stellate Cell Activation and Liver Fibrosis by Activating RhoA Signaling. Molecular Therapy Nucleic Acids. 2018, 12:57-66.

    (111)      Yan Li*, Shuhai Lin , Lei Li, Zhi Tang, Yumin Hu , Xiaojiao Ban, Tingting Zeng, Ying Zhou, Yinghui Zhu, Song Gao, Wen Deng, Xiaoshi Zhang, Dan Xie, Yunfei Yuan, Peng Huang, Jinjun Li, Zongwei Cai, Xin-Yuan Guan*. PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration and reprogramming glucose metabolism. Cancer Res. 2018,78(16):4471-4481

    (112)      Pengbo Cao, Aiqing Yang, Rui Wang, Xia Xia, Yun Zhai, Yuanfeng Li, Fei Yang, Ying Cui, Weimin Xie, Ying Liu, Taotao Liu, Weihua Jia, Zhengwen Jiang, Zhuo Li, Yuqing Han, Chengming Gao, Qingfeng Song, Bobo Xie, Luo Zhang, Hongxing Zhang, Jinxu Zhang, Xizhong Shen, Yunfei Yuan环球体育平台登录, Feng Yu, Ying Wang, Jing Xu, Yilong Ma, Zengnan Mo, Wuzhong Yu, Fuchu He*, and Gangqiao Zhou*.  Gastroenterology. 2018, 155:542-556

    (113)      Sheng-Long Ye*, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima and Zhengguang Lv. Safety assessment of sorafenib in Chinese patients with unresectable hepatocellular carcinoma: subgroup analysis of the GIDEON study. BMC Cancer 2018, 18:247

    (114)      Yun Wang, Haocheng Lin, Mayan Huang, Qiong Shao, Zhiqiang Wang, Fenghua Wang, Yunfei Yuan环球体育平台登录,Binkui Li,Deshen Wang,Peirong Ding,Gong Chen,Xiaojun Wu,Zhenhai Lu, Liren Li, Zhizhong Pan, Peng Sun, Shumei Yan, Desen Wan, Ruihua Xu*, Yuhong Li*. Cancer Immunol Immunother. 2018, 67(3):435-444.

    (115)        Xue-Jia Lin, Jian-Hong Fang, Xiao-Jing Yang, Chong Zhang, Yunfei Yuan环球体育平台登录, Limin Zheng, and Shi-Mei Zhuang*.  Molecular Therapy Nucleic Acids. 2018, 11:243-252.

    (116)      Sarah T. K. Sin, Yan Li, Ming Liu, Yun-Fei Yuan环球体育平台登录, Stephanie Ma, and Xin-Yuan Guan*.  Hepatology Communications. 2018, 2(11):1408-1414.

    (117)      Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Terence K. Lee, Rakesh Sharma, Jane H. Loong, Yick Pang Ching, Yun-Fei Yuan, Dan Xie, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H. Yan, Suet Yi Leung, Ste´phane Richard, Xin-Yuan Guan, Michael S.Y. Huen, and Stephanie Ma*.  Cell Reports. 2018, 25(3):690-701.

    (118)      Yongdong Dai, Lulu Liu, Tingting Zeng, Jian-Zhong Liang, Ye Song, Kai Chen, Yan Li, Leilei Chen, Ying-Hui Zhu, Jiangchao Li, Yan Li, Dan Xie, Yun-Fei Yuan环球体育平台登录, Xin-Yuan Guan*. Overexpression of MUC13, a Poor Prognostic Predictor, Promotes Cell Growth by Activating Wnt Signaling in Hepatocellular Carcinoma, The American Journal of Pathology 2018, 188(2):378-391


    2019:

    (119)      Zhiwen Yang, Ruhai Zou, Yun Zheng, Jiliang Qiu, Jingxian Shen, Yadi Liao, Yuanping Zhang, Chenwei Wang, Yongjin Wang, Yichuan Yuan, Kai Li, Dinglan Zuo & Wei He, Wenwu Liu, Binkui Li*, Yunfei Yuan*. Lipiodol deposition in portal vein tumour thrombus predicts treatment outcome in HCC patients after transarterial chemoembolisation. European Radiology 2019. (2018 IF=3.962 )

    (120)      Wenwu Liu, Zhiwen Yang, Ruhai Zou, Jiliang Qiu, Jingxian Shen, Yadi Liao, Chenwei Wang, Yuanping Zhang, Yongjin Wang, Yichuan Yuan, Kai Li, Dinglan Zuo, Wei He, Yun Zheng*, Binkui Li*, Yunfei Yuan*. Resection vs Ablation for Multifocal Hepatocellular Carcinomas meeting the Barcelona-Clinic Liver Cancer A Classification: A Propensity Score Matching Study. Journal of Cancer 2019; 10(13):2857-2867. (2018 IF=3.182 )

    (121)      Wenwu Liu, Ruhai Zou, Chenwei Wang, Jiliang Qiu, Jingxian Shen, Yadi Liao, Zhiwen Yang, Yuanping Zhang, Yongjin Wang, Yichuan Yuan, Kai Li, Dinglan Zuo, Wei He, Yun Zheng, Binkui Li and Yunfei Yuan*. Microwave ablation versus resection for hepatocellular carcinoma within the Milan criteria: a propensity-score analysis. Therapeutic Advances in Medical Oncology 2019, 11: 1–13 (2018 IF= 5.670)



    环球体育平台登录更新日期:2020年2月24日

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